Precision and personalized vaccines needed to face COVID-19 pandemic

Among the abounding lessons we learned from SARS-C0V-2 pandemic is uttermost determinant that people are not equal before severity of COVID-19. Indeed, disease course differs with age, gender, ethnicity, underlying clinical conditions and virus variants. Other diseases modifying factors associated genetic traits such as those driving immune response, blood groups, coagulation system ACE2 receptor variants [1-4].